SGBC -IITM

Sudha Gopalakrishnan Brain Centre

Indian Institute of Technology Madras

DHARANI: A 3D Developing Human-brain Atlas Resource to Advance Neuroscience Internationally -- Integrated Multimodal Imaging and High-resolution Histology of the second trimester

Paper accepted for publication by Journal of Comparative Neurology

Commentary from Editor-in-Chief

Datasets

Brains	Gestation week(GW)	Sectioning Plane	Available Datasets	Annotations	Volumes	Videos
Specimen 1	14	Sagittal	Nissl (395) H&E (341)	63 (sections)	MRI Nissl Nissl(Grayscale)	3D Axial Coronal Sagittal
Specimen 2	17	Sagittal	Nissl (536) H&E (485)	90 (sections)	MRI Nissl Nissl(Grayscale)	3D Axial Coronal Sagittal
Specimen 3	21	Sagittal	Nissl (540) H&E (467)	69 (sections)	MRI Nissl Nissl(Grayscale)	3D Axial Coronal Sagittal
Specimen 4	22	Coronal	Nissl (689) H&E (687)	124 (sections)	MRI Nissl Nissl(Grayscale)	3D Axial Coronal Sagittal
Specimen 5	24	Para (Sagittal)	Nissl (657) H&E (335)	120 (sections)	MRI Nissl Nissl(Grayscale)	3D Axial Coronal Sagittal

Fly through Videos

Axial

Sagittal

Coronal

3D Video

The Sudha Gopalakrishnan Brain Centre of IIT Madras operates a world-class high-throughput multimodal whole-brain histology-imaging-compute pipeline, to digitize and study human brains at unprecedented high-resolution and scale. The centre leverages expertise across IITM, national, and international collaborations, and aims become a globally leading R&D centre for human brain research with transformative impact in neuroscience and neurotechnologies.